One of our testers experienced issues when trying to calibrate and save their configuration.
What solved this issue for our tester was a fresh calibration of the Thrustmaster TCA quadrant. Fresh calibration guides are available from the Thrustmaster website. We do recommend that you will need to calibrate the flap and speedbrake lever as well, during the fresh calibration.
Once complete, our tester was able to save Thrustmaster calibration settings within Fenix.